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These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, fibrates, ginseng); stimulating insulin secretion (salicylates, disopyramide, quinine, quinidine, MAOIs, ginseng); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs). In doses several times higher than those used to treat malaria, quinine may stimulate the pregnant uterus. The rate of spontaneous abortion was lower in women treated with quinine (3. The quinine is known to stop muscle cramping and it has stopped my muscle cramps/spasms, and it might help you. The overall rate of congenital malformations was not different for women treated with quinine (1. Quinine was used starting in the 17th century as a prophylactic against malaria. The agency urges consumers who are using quinine products and have questions or concerns to contact their health care provider. Quinine is considered compatible with breast-feeding by the American Academy of Pediatrics. “We believe unapproved quinine products represent a serious health risk because of the widespread use of this product for treating leg cramps. The FDA-approved labeling for the product provides extensive warnings regarding serious adverse events associated with use of quinine, potentially serious interactions with other drugs, and conditions under which quinine should not be used. Quinine drugs are associated with serious side effects, such as cardiac arrhythmias, thrombocytopenia (a decrease in blood platelets that can cause hemorrhage or clotting problems), and severe hypersensitivity reactions. However, there is only one quinine product approved by the FDA.

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